BDBM535430 (3R)-3-(4-chlorophenyl)-4-fluoro-6-[1- hydroxy-1-(1-methyl-1H-pyrazol-4- yl)ethyl]-3-[(1- hydroxycyclopropyl)methoxy]-2-[(5- methylpyridin-2-yl)methyl]-2,3- dihydro-1H-isoindol-1-one::US11236047, Example 227::US20230338337, Compound 227

SMILES Cc1ccc(CN2C(=O)c3cc(cc(F)c3[C@]2(OCC2(O)CC2)c2ccc(Cl)cc2)C(C)(O)c2cnn(C)c2)nc1

InChI Key InChIKey=DKOKUKMQYMDUPS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535430   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535430BDBM535430((3R)-3-(4-chlorophenyl)-4-fluoro-6-[1- hydroxy-1-(...)
Affinity DataIC50: 4.80nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535430BDBM535430((3R)-3-(4-chlorophenyl)-4-fluoro-6-[1- hydroxy-1-(...)
Affinity DataIC50: 4.80nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent