BDBM535460 6-{[1-(4-chlorophenyl)-7-fluoro-5-[1- hydroxy-1-(1-methyl-1H-pyrazol-4- yl)ethyl]-3-oxo-1-[cis-3- hydroxycyclobutoxy]-2,3-dihydro-1H- isoindol-2-yl]methyl}pyridine-3- carbonitrile Ex. 356 is the slower eluting isomer::US11236047, Example 356

SMILES Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(C#N)cn2)[C@@]3(O[C@H]2C[C@@H](O)C2)c2ccc(Cl)cc2)cn1

InChI Key InChIKey=PLLUZPZNYWOMRY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535460   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535460BDBM535460(6-{[1-(4-chlorophenyl)-7-fluoro-5-[1- hydroxy-1-(1...)
Affinity DataIC50: 5.90nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent