BDBM535466 US11236068, Example 63a::US11236068, Example 63b

SMILES C[C@H]1CN(CCN1c1nc(OC[C@@H]2CCCN2C)nc2c(F)c(c(Cl)cc12)-c1nc(N)cc2ccccc12)C(=O)C=C

InChI Key InChIKey=QVNCYWXYBHWCQO-ICSRJNTNSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535466   

TargetGTPase KRas [G12C](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM535466(US11236068, Example 63a | US11236068, Example 63b)
Affinity DataIC50:  160nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12C](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM535466(US11236068, Example 63a | US11236068, Example 63b)
Affinity DataIC50:  7nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent