BDBM535753 6-{[(1R)-1-(4-chlorophenyl)-5- [cyclopropyl(hydroxy)(1-methyl-1H- imidazol-4-yl)methyl]-7-fluoro-3-oxo- 1-[(3S)-oxolan-3-yloxy]-2,3-dihydro- 1H-isoindol-2-yl]methyl}pyridine-3- carbonitrile::US11236047, Example 433::US11236047, Example 434

SMILES Cn1cnc(c1)C(O)(C1CC1)c1cc2C(=O)N(Cc3ccc(cn3)C#N)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=DQSUJJZOQXTIMY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535753   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535753BDBM535753(6-{[(1R)-1-(4-chlorophenyl)-5- [cyclopropyl(hydrox...)
Affinity DataIC50: 1.30nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535753BDBM535753(6-{[(1R)-1-(4-chlorophenyl)-5- [cyclopropyl(hydrox...)
Affinity DataIC50: 11nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent