BDBM535769 (3R)-3-(4-Chlorophenyl)-3-{[1- (hydroxymethyl)cyclopropyl]methoxy}- 6-(2-hydroxypropan-2-yl)-2-[(5- methylpyrazin-2-yl)methyl]-2,3- dihydro-1H-isoindol-1-one::US11236047, Example 460::US20230338337, Compound 460

SMILES Cc1cnc(CN2C(=O)c3cc(ccc3[C@]2(OCC2(CO)CC2)c2ccc(Cl)cc2)C(C)(C)O)cn1

InChI Key InChIKey=ZWMXXGFGENSWSG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535769   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535769BDBM535769((3R)-3-(4-Chlorophenyl)-3-{[1- (hydroxymethyl)cycl...)
Affinity DataIC50: 480nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535769BDBM535769((3R)-3-(4-Chlorophenyl)-3-{[1- (hydroxymethyl)cycl...)
Affinity DataIC50: 480nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent