BDBM535781 (3R)-3-(4-chlorophenyl)-2-[(5- chloropyrimidin-2-yl)methyl]-4-fluoro- 6-[(1R)-1-(4-fluorooxan-4-yl)-1- hydroxypropyl]-3-(2-hydroxyethoxy)- 2,3-dihydro-1H-isoindol-1-one::US11236047, Example 501

SMILES CC[C@@](O)(c1cc2C(=O)N(Cc3ncc(Cl)cn3)[C@](OCCO)(c2c(F)c1)c1ccc(Cl)cc1)C1(F)CCOCC1

InChI Key InChIKey=CPLOBKSITDKJJL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535781   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535781BDBM535781((3R)-3-(4-chlorophenyl)-2-[(5- chloropyrimidin-2-y...)
Affinity DataIC50: 3.10nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent