BDBM535791 1-({[(1R)-1-(4-chlorophenyl)-2-[(5- chloropyrimidin-2-yl)methyl]-7-fluoro- 5-[2-hydroxy-1-(4-methylpiperazin-1- yl)butan-2-yl]-3-oxo-2,3-dihydro-1H- isoindol-1- yl]oxy}methyl)cyclopropane-1- carbonitrile Ex. 534 is the faster eluting isomer::US11236047, Example 534

SMILES CCC(O)(CN1CCN(C)CC1)c1cc2C(=O)N(Cc3ncc(Cl)cn3)[C@](OCC3(CC3)C#N)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=GJZOHGAQYXUXCM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535791   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535791BDBM535791(1-({[(1R)-1-(4-chlorophenyl)-2-[(5- chloropyrimidi...)
Affinity DataIC50: 8.80nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent