BDBM535797 2-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 1-({1- [hydroxydideuteromethyl]cyclopropyl} dideuteromethoxy)-5-(2- hydroxypropan-2-yl)-3-oxo-2,3- dihydro-1H-isoindol-2- yl]methyl}pyrimidine-5-carbonitrile::US11236047, Example 513

SMILES CC(C)(O)c1cc2C(=O)N(Cc3ncc(cn3)C#N)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=XJGKRRJKFHLFEF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535797   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535797BDBM535797(2-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 1-({1- [hydr...)
Affinity DataIC50: 3.10nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
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Date in BDB:
6/6/2022
Entry Details
US Patent