BDBM535805 3-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[(1R)-1-(4-fluorooxan-4-yl)-1- hydroxypropyl]-1-methoxy-3-oxo-2,3- dihydro-1H-isoindol-2-yl]methyl}-6- methylpyridine-2-carboxylic acid::US11236047, Example 515

SMILES CC[C@@](O)(c1cc2C(=O)N(Cc3ccc(C)nc3C(O)=O)[C@](OC)(c2c(F)c1)c1ccc(Cl)cc1)C1(F)CCOCC1

InChI Key InChIKey=XSHRXYPCIVWDNP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535805   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535805BDBM535805(3-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[(1R)-1-(4...)
Affinity DataIC50: 1.40nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent