BDBM535806 2-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydroxy-1-(1-methyl-1H-pyrazol- 3-yl)propyl]-3-oxo-1-[(3S)-oxolan-3- yloxy]-2,3-dihydro-1H-isoindol-2- yl]methyl}pyrimidine-5-carbonitrile::US11236047, Example 490

SMILES CCC(O)(c1ccn(C)n1)c1cc2C(=O)N(Cc3ncc(cn3)C#N)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=HYWAMQVGJDJCMR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535806   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535806BDBM535806(2-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydroxy...)
Affinity DataIC50: 2.30nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent