BDBM536035 US11242337, Example 142

SMILES Clc1cc2[C@H](Oc3ccc(cc3)S(=O)(=O)N[C@@H]3CCN(C3)C(=O)CCCNC(=O)NCCCCNC(=O)NCCCC(=O)N3CC[C@H](C3)NS(=O)(=O)c3ccc(O[C@@H]4[C@H](Cc5c4cc(Cl)cc5C#N)N4CCNCC4)cc3)[C@H](Cc2c(c1)C#N)N1CCNCC1

InChI Key InChIKey=BBWIGVCHVGSHQE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 536035   

TargetSodium/hydrogen exchanger 3(Human)
Ardelyx

US Patent
LigandPNGBDBM536035(US11242337, Example 142)
Affinity DataIC50: 100nMAssay Description:Rat and human NHE-3-mediated Na+-dependent H+ antiport was measured using a modification of the pH sensitive dye method originally reported by Paradi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

TargetSodium/hydrogen exchanger 3(Human)
Ardelyx

US Patent
LigandPNGBDBM536035(US11242337, Example 142)
Affinity DataIC50: 100nMAssay Description:The ability of compounds to inhibit human and rat NHE-3-mediated Na+ dependent H+ antiport after application and washout was measured using a modific...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent