BDBM536224 6-(4-(2-((4R)-4-Hydroxy-1-(3-methyl-2-(3-methylisoxazol-5-yl)butanoyl) pyrrolidin-2-yl)-5-methyl-4-oxo-4,5-dihydro-1H-imidazol-5-yl) phenyl)-1-methylpyridin-2(1H)-one::US11242344, Example 108.1

SMILES Cc1cc(C(C(=O)N2C[C@H](O)C[C@H]2C2=NC(=O)[C@](C)(c3ccc(-c4cccc(=O)n4C)cc3)N2)C(C)C)on1

InChI Key InChIKey=NVXRTBAQPIGSRM-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 536224   

LigandChemical structure of BindingDB Monomer ID 536224BDBM536224(6-(4-(2-((4R)-4-Hydroxy-1-(3-methyl-2-(3-methyliso...)
Affinity DataKd:  1.39E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536224BDBM536224(6-(4-(2-((4R)-4-Hydroxy-1-(3-methyl-2-(3-methyliso...)
Affinity DataIC50: 5.75E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent