BDBM536265 1-((4R)-2-(1,1-dioxido-4,5-dihydro-1,2,4-thiadiazol-3-yl)-4-hydroxypyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one::US11242344, Example 137.1

SMILES Cc1cc([C@H](C(=O)N2C[C@H](O)C[C@H]2C2=NS(=O)(=O)CN2)C(C)C)on1

InChI Key InChIKey=ICHGUTYOUFXFKE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 536265   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 536265BDBM536265(1-((4R)-2-(1,1-dioxido-4,5-dihydro-1,2,4-thiadiazo...)
Affinity DataIC50: 1.00E+5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536265BDBM536265(1-((4R)-2-(1,1-dioxido-4,5-dihydro-1,2,4-thiadiazo...)
Affinity DataIC50: 4.00E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent