BDBM536287 US11242344, Example 1003.3

SMILES CC/C(=C(\c1ccc(O)cc1)c1ccc(OCCN(C)C(=O)CCCOCCOc2cc([C@@H](C(=O)N3C[C@H](O)C[C@H]3C3=NC(=O)[C@](C)(c4ccc(-c5scnc5C)cc4)N3)C(C)C)on2)cc1)c1ccccc1

InChI Key InChIKey=YNNSZAHUAIODTC-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 536287   

LigandChemical structure of BindingDB Monomer ID 536287BDBM536287(US11242344, Example 1003.3)
Affinity DataIC50: 3.04E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 536287BDBM536287(US11242344, Example 1003.3)
Affinity DataIC50: 5.16E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536287BDBM536287(US11242344, Example 1003.3)
Affinity DataKd:  6.71E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent