BDBM536287 US11242344, Example 1003.3

SMILES CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C(=O)CCCOCCOc2cc(on2)[C@H](C(C)C)C(=O)N2C[C@H](O)C[C@H]2C2=NC(=O)[C@@](C)(N2)c2ccc(cc2)-c2scnc2C)cc1)c1ccccc1

InChI Key InChIKey=YNNSZAHUAIODTC-SZPJVTDJSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 536287   

LigandPNGBDBM536287(US11242344, Example 1003.3)
Affinity DataIC50:  3.04E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM536287(US11242344, Example 1003.3)
Affinity DataIC50:  5.16E+4nMAssay Description:The VHL NanoBRET™ Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL Nano...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536287(US11242344, Example 1003.3)
Affinity DataKd:  6.71E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent