BDBM538051 4-(2-fluoro-5-((4-oxo- 3,4-dihydrophthalazin-1- yl)methyl)phenyl)-N,N- dimethyl-1,4- azaphosphinane-1- carboxamide 4-oxide::US11248013, Example 9

SMILES CN(C)C(=O)N1CCP(=O)(c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1

InChI Key InChIKey=OTUFIKSADHPTNT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 538051   

TargetPoly [ADP-ribose] polymerase 1(Human)
Rakovina Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 538051BDBM538051(4-(2-fluoro-5-((4-oxo- 3,4-dihydrophthalazin-1- yl...)
Affinity DataIC50: 550nMAssay Description:Inhibition of PARP-1 enzymatic activities was measured using an HT Universal Colorimetric PARP Assay Kit (Trevigen, catalogue #4677-096-K) following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent