BDBM5420 4-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]pyridine::CHEMBL329350::pyrazolo[1,5-a]pyrimidine 2c

SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1

InChI Key InChIKey=ZBCIUJVPXUPSFS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5420   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5420(CHEMBL329350 | 4-[6-(4-methoxyphenyl)pyrazolo[1,5-...)
Affinity DataIC50: 37nMpH: 7.4 T: 2°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2005
Entry Details Article
PubMed
TargetBone morphogenetic protein 4(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM5420(CHEMBL329350 | 4-[6-(4-methoxyphenyl)pyrazolo[1,5-...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of BMP4-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed