BDBM542609 US11274105, Example 100::US11274105, Example 101::US11274105, Example 102::US11274105, Example 99

SMILES CC[C@@H]1C(=O)N(C)CC\C=C\[C@H](O)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)[C@@]1(O)C(O)=O

InChI Key InChIKey=DVEWUKBAMRKWSJ-UHFFFAOYSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 542609   

LigandPNGBDBM542609(US11274105, Example 101 | US11274105, Example 100 ...)
Affinity DataIC50: 44.4nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent

LigandPNGBDBM542609(US11274105, Example 101 | US11274105, Example 100 ...)
Affinity DataIC50: 984nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent

LigandPNGBDBM542609(US11274105, Example 101 | US11274105, Example 100 ...)
Affinity DataIC50: 13.1nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent

LigandPNGBDBM542609(US11274105, Example 101 | US11274105, Example 100 ...)
Affinity DataIC50: 295nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent

LigandPNGBDBM542609(US11274105, Example 101 | US11274105, Example 100 ...)
Affinity DataIC50: 1.00E+3nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent

LigandPNGBDBM542609(US11274105, Example 101 | US11274105, Example 100 ...)
Affinity DataIC50: 3.95E+3nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent

LigandPNGBDBM542609(US11274105, Example 101 | US11274105, Example 100 ...)
Affinity DataIC50: 54.5nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent

LigandPNGBDBM542609(US11274105, Example 101 | US11274105, Example 100 ...)
Affinity DataIC50: 341nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent

LigandPNGBDBM542609(US11274105, Example 101 | US11274105, Example 100 ...)
Affinity DataKi:  1.98nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2022
Entry Details
US Patent