BDBM544288 US11285156, Ex.# 132-1

SMILES COc1cc(-c2nc3n(-c4c(C)ccnc4C(C)C)c(=O)nc(N4C[C@@H](C)N(C[C@@H]4C)C(=O)C=C)c3cc2Cl)c2ccccc2c1

InChI Key InChIKey=ZCFLGVFAHHHEPL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544288   

TargetGTPase KRas [1-169,G12C,C118A](Human)
Amgen

US Patent
LigandPNGBDBM544288(US11285156, Ex.# 132-1)
Affinity DataIC50: 53nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent