BDBM548504 WO2022093881, Ex-10.13

SMILES C[C@]1(COC[C@@H]1O)N1CCN(CC1)c1cc2cc(NC(=O)[C@H]3C[C@H]3c3cccs3)ncc2cc1Cl

InChI Key InChIKey=BSHUMBAMHULABR-KXFHSJCDSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 548504   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
MERCK SHARP & DOHME LLC

WIPO
LigandPNGBDBM548504(WO2022093881, Ex-10.13)
Show SMILES C[C@]1(COC[C@@H]1O)N1CCN(CC1)c1cc2cc(NC(=O)[C@H]3C[C@H]3c3cccs3)ncc2cc1Cl
Show InChI InChI=1S/C26H29ClN4O3S/c1-26(15-34-14-23(26)32)31-6-4-30(5-7-31)21-10-16-11-24(28-13-17(16)9-20(21)27)29-25(33)19-12-18(19)22-3-2-8-35-22/h2-3,8-11,13,18-19,23,32H,4-7,12,14-15H2,1H3,(H,28,29,33)/t18-,19+,23+,26-/m1/s1
Affinity DataIC50: 0.0800nMAssay Description: The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid