BDBM550795 8-(8-Methylquinolin-6-yl)-7-phenyl-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine 5::US11312705, Example 5

SMILES Cc1cc(cc2cccnc12)-c1c(nc(N)n2cnnc12)-c1ccccc1

InChI Key InChIKey=KDGKRRSVUPFUSN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 550795   

TargetAdenosine receptor A2a(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550795(8-(8-Methylquinolin-6-yl)-7-phenyl-[1,2,4]triazolo...)
Affinity DataIC50: 0.0900nMAssay Description:CHO-K1/A2aR cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 800 μg/ml bleomycin. The cells were digested with the c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
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TargetAdenosine receptor A2a(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550795(8-(8-Methylquinolin-6-yl)-7-phenyl-[1,2,4]triazolo...)
Affinity DataIC50: 0.0900nMAssay Description:CHO-K1/A2aR cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 800 μg/ml bleomycin. The cells were digested with the c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetAdenosine receptor A3(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550795(8-(8-Methylquinolin-6-yl)-7-phenyl-[1,2,4]triazolo...)
Affinity DataIC50: 1.40nMAssay Description:CHO-K1/A3R cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 10 μg/ml puromycin. The cells were digested with the cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetAdenosine receptor A1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550795(8-(8-Methylquinolin-6-yl)-7-phenyl-[1,2,4]triazolo...)
Affinity DataIC50: 12nMAssay Description:CHO-K1/A1R cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 1 mg/ml G418. The cells were digested with the cell separatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent