BDBM552972 N-[4-fluoro-2-[(3R,5S)- 3,4,5-trimethylpiperazin- 1-yl]phenyl]-6-oxo-4- (trifluoromethyl)-1H- pyridine-3-carboxamide::US11319299, Example 26

SMILES C[C@@H]1CN(c2cc(F)ccc2NC(=O)c2c[nH]c(=O)cc2C(F)(F)F)C[C@H](C)N1C

InChI Key InChIKey=MSVVEQMGBXUFDN-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 552972   

TargetWD repeat-containing protein 5(Human)
Propellon Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 552972BDBM552972(N-[4-fluoro-2-[(3R,5S)- 3,4,5-trimethylpiperazin- ...)
Affinity DataKd:  42.5nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
US Patent

TargetMLL1-WRAD2 complex(Human)
Propellon Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 552972BDBM552972(N-[4-fluoro-2-[(3R,5S)- 3,4,5-trimethylpiperazin- ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
US Patent