BDBM553000 (R)-N-(4-(3,4- dimethylpiperazin-1-yl)-6- fluoro-3'- (morpholinomethyl)-[1,1'- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3- carboxamide::US11319299, Example 50
SMILES C[C@@H]1CN(CCN1C)c1cc(F)c(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cccc(CN2CCOCC2)c1
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 553000
Affinity DataKd: 12nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
Affinity DataIC50: 9.41E+3nMAssay Description:Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a...More data for this Ligand-Target Pair