BDBM553000 (R)-N-(4-(3,4- dimethylpiperazin-1-yl)-6- fluoro-3'- (morpholinomethyl)-[1,1'- biphenyl]-3-yl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyridine-3- carboxamide::US11319299, Example 50

SMILES C[C@@H]1CN(CCN1C)c1cc(F)c(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cccc(CN2CCOCC2)c1

InChI Key

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 553000   

TargetWD repeat-containing protein 5(Homo sapiens (Human))
Propellon Therapeutics

US Patent
LigandPNGBDBM553000((R)-N-(4-(3,4- dimethylpiperazin-1-yl)-6- fluoro-3...)
Affinity DataKd:  12nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMLL1-WRAD2 complex(Homo sapiens (Human))
Propellon Therapeutics

US Patent
LigandPNGBDBM553000((R)-N-(4-(3,4- dimethylpiperazin-1-yl)-6- fluoro-3...)
Affinity DataIC50:  9.41E+3nMAssay Description:Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent