BDBM555466 US11344549, Example 142

SMILES CSCCCn1cc(Nc2ncc(C(N)=O)c(NCc3c(F)cccc3F)n2)cn1

InChI Key InChIKey=ZNWNXSQUGSWVDM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 555466   

TargetTyrosine-protein kinase JAK3(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555466(US11344549, Example 142)
Affinity DataIC50: 0.240nMAssay Description:JAK3 (the final concentration was 0.36 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555466(US11344549, Example 142)
Affinity DataIC50: 0.760nMAssay Description:JAK2 (the final concentration was 0.25 nM); ATP (the final concentration was 5 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Beijing Scitech Mq Pharmaceuticals

US Patent
LigandPNGBDBM555466(US11344549, Example 142)
Affinity DataIC50: 16.6nMAssay Description:JAK1 (the final concentration was 10 nM); ATP (the final concentration was 10 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentrati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent