BDBM558803 (R)-1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-(3-(pyrrolidin-1-::US11365205, Example 70

SMILES O[C@@H](CN1CCN(Cc2cccc(c2)S(=O)(=O)N2CCCC2)C1=O)CN1CCc2ccccc2C1

InChI Key InChIKey=BGTDOBZVBMNXKM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 558803   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Aurigene Discovery Technologies

US Patent
LigandChemical structure of BindingDB Monomer ID 558803BDBM558803((R)-1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydro...)
Affinity DataIC50: 130nMAssay Description:Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyze mono- and symmetric demethylation on arginine resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent