BDBM558830 1-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-(4-methoxybenzyl)-::US11365205, Example 94

SMILES COc1ccc(Cn2c3ncccc3n(CC(O)CN3CCc4ccccc4C3)c2=O)cc1

InChI Key InChIKey=PMDWLSNCRHMECM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 558830   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Aurigene Discovery Technologies

US Patent
LigandChemical structure of BindingDB Monomer ID 558830BDBM558830(1-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypr...)
Affinity DataIC50: 430nMAssay Description:Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyze mono- and symmetric demethylation on arginine resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent