BDBM558835 6-43-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-oxo-2,3-dihydro-::US11365205, Example 99

SMILES OC(CN1CCc2ccccc2C1)Cn1c2ncccc2n(Cc2ccc(cn2)C#N)c1=O

InChI Key InChIKey=DOFFNHBABIEYIT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 558835   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Aurigene Discovery Technologies

US Patent
LigandChemical structure of BindingDB Monomer ID 558835BDBM558835(6-43-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydrox...)
Affinity DataIC50: 210nMAssay Description:Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyze mono- and symmetric demethylation on arginine resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent