BDBM560635 (2R,4R)-4-((3-fluoro-6- ((5-methyl-1H-pyrazol-3- yl)amino)pyridin-2-yl) methyl)-2-methyl-1-(3- (trifluoromethyl)benzyl) piperidine-4-carboxylic acid::US11384066, Example 21

SMILES Cc1cc(Nc2ccc(F)c(C[C@@]3(C(=O)O)CCN(Cc4cccc(C(F)(F)F)c4)[C@H](C)C3)n2)n[nH]1

InChI Key InChIKey=JNUOYJIFPAGVNI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 560635   

TargetAurora kinase A(Human)
Jacobio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 560635BDBM560635(US11384066, Example 21 | (2R,4R)-4-((3-fluoro-6- (...)
Affinity DataIC50: 3.10nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent

TargetAurora kinase B(Human)
Jacobio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 560635BDBM560635(US11384066, Example 21 | (2R,4R)-4-((3-fluoro-6- (...)
Affinity DataIC50: 5.55E+3nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent