BDBM560641 (2R,4R)-1-(3-chloro-2- fluorobenzyl)-2-methyl-4- ((5-methyl-6-((5-methyl- 1H-pyrazol-3-yl)amino) pyrazin-2-yl)methyl) piperidine-4-carboxylic acid::US11384066, Example 33

SMILES Cc1cc(Nc2nc(C[C@@]3(C(=O)O)CCN(Cc4cccc(Cl)c4F)[C@H](C)C3)cnc2C)n[nH]1

InChI Key InChIKey=SOCFAEWXYJEKPE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 560641   

TargetAurora kinase A(Human)
Jacobio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 560641BDBM560641(US11384066, Example 33 | (2R,4R)-1-(3-chloro-2- fl...)
Affinity DataIC50: 1.5nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent

TargetAurora kinase B(Human)
Jacobio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 560641BDBM560641(US11384066, Example 33 | (2R,4R)-1-(3-chloro-2- fl...)
Affinity DataIC50: 5.64E+3nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent