BDBM560643 (2R,4R)-1-(2-(3-chloro-2- fluorophenyl)acetyl)-4-((3- fluoro-6-((5-methyl-1H- pyrazol-3-yl)amino)pyri- din-2-yl)methyl)-2-methyl- piperidine-4-carboxylic acid::US11384066, Example 38

SMILES Cc1cc(Nc2ccc(F)c(C[C@@]3(C(=O)O)CCN(C(=O)Cc4cccc(Cl)c4F)[C@H](C)C3)n2)n[nH]1

InChI Key InChIKey=ZBLXMVSBOPAZEE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 560643   

TargetAurora kinase A(Human)
Jacobio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 560643BDBM560643(US11384066, Example 38 | (2R,4R)-1-(2-(3-chloro-2-...)
Affinity DataIC50: 0.850nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent

TargetAurora kinase B(Human)
Jacobio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 560643BDBM560643(US11384066, Example 38 | (2R,4R)-1-(2-(3-chloro-2-...)
Affinity DataIC50: 838nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent