BDBM562726 2-(5-Chloro-2-thienyl)-6-cyclopropyl-N-[4-(1H-tetrazol-5-ylmethyl)phenyl]pyrimidin-4-amine::US11401286, Example 298

SMILES Clc1ccc(s1)-c1nc(Nc2ccc(Cc3nnn[nH]3)cc2)cc(n1)C1CC1

InChI Key InChIKey=IAMUULWJEBHQNE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 562726   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D7 [S54D](Human)
Tetra Discovery Partners

US Patent
LigandPNGBDBM562726(US11401286, Example 298 | 2-(5-Chloro-2-thienyl)-6...)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays are performed in 96-well plates in a total volume of 200 μl/well. Compounds are dissolved in dimethylsulfoxide (DMSO) and added to plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

TargetIsoform 7 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Tetra Discovery Partners

US Patent
LigandPNGBDBM562726(US11401286, Example 298 | 2-(5-Chloro-2-thienyl)-6...)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays are performed in 96-well plates in a total volume of 200 μl/well. Compounds are dissolved in dimethylsulfoxide (DMSO) and added to plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [S133D](Human)
Tetra Discovery Partners

US Patent
LigandPNGBDBM562726(US11401286, Example 298 | 2-(5-Chloro-2-thienyl)-6...)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays are performed in 96-well plates in a total volume of 200 μl/well. Compounds are dissolved in dimethylsulfoxide (DMSO) and added to plates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent