BDBM562785 (R)-4-((2S,3R,6S)-2,3-Bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholino)heptanoic acid and (S)-4-((2R,3S,6R)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholino)heptanoic acid::US11407721, Example 31

SMILES CCC[C@@H](CCC(O)=O)N1[C@@H]([C@@H](O[C@H](Cc2ccc(F)cc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1

InChI Key InChIKey=PTHOVXLFQNARAG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 562785   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562785BDBM562785(US11407721, Example 31 | (R)-4-((2S,3R,6S)-2,3-Bis...)
Affinity DataIC50: 1.33E+3nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
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Date in BDB:
10/28/2022
Entry Details
US Patent