BDBM562811 (2S,5R,6S)-5,6-Bis(4-chlorophenyl)-4-(2-chloropyridin-4-yl)-2-(4-fluorobenzyl)morpholin-3-one and (2R,5S,6R)-5,6-bis(4-chlorophenyl)-4-(2-chloropyridin-4-yl)-2-(4-fluorobenzyl)morpholin-3-one::US11407721, Example 58

SMILES Fc1ccc(C[C@H]2O[C@@H]([C@@H](N(C2=O)c2ccnc(Cl)c2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1

InChI Key InChIKey=KDMZQPXBRXKOKS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 562811   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562811BDBM562811(US11407721, Example 58 | (2S,5R,6S)-5,6-Bis(4-chlo...)
Affinity DataIC50: 5.00E+3nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent