BDBM562829 (3R,4S,8R)-4-(3-Chlorophenyl)-3-(4-chlorophenyl)-2-isopropyltetrahydropyrrolo[1,2-a]pyrazine-1,6(2H,7H)-dione::US11407721, Example 76

SMILES CC(C)N1[C@@H]([C@@H](N2[C@H](CCC2=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key InChIKey=VFQSDHHWNIJHMY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 562829   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562829BDBM562829(US11407721, Example 76 | (3R,4S,8R)-4-(3-Chlorophe...)
Affinity DataIC50: 3.63E+3nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent