BDBM562833 (2S,5R,6S)-5,6-Bis(4-chlorophenyl)-2-(4-fluorobenzyl)morpholin-3-one::US11407721, Example 80

SMILES Fc1ccc(C[C@@H]2O[C@H]([C@H](NC2=O)c2ccc(Cl)cc2)c2ccc(Cl)cc2)cc1

InChI Key InChIKey=NNHHVXDUFOZJBY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 562833   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562833BDBM562833(US11407721, Example 80 | (2S,5R,6S)-5,6-Bis(4-chlo...)
Affinity DataIC50: 973nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562833BDBM562833(US11407721, Example 80 | (2S,5R,6S)-5,6-Bis(4-chlo...)
Affinity DataIC50: 4.94E+3nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent