BDBM567912 (R)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)methyl)-6-(3,4-difluorophenyl)pyridin-3-yl)piperidin-3-yl)-2,2-difluoroethan-1-ol and (S)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)methyl)-6-(3,4-difluorophenyl)pyridin-3-yl)piperidin-3-yl)-2,2-difluoroethan-1-ol::US11420970, Example 113

SMILES Nc1ncnc2n(Cc3cc(ncc3N3CCC[C@@](N)(C3)[C@@H](O)C(F)F)-c3ccc(F)c(F)c3)cnc12

InChI Key InChIKey=DINCKUGYLLIMMO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 567912   

TargetHistone-lysine N-methyltransferase NSD2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 567912BDBM567912((R)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)me...)
Affinity DataIC50: 525nMAssay Description:This assay employed LC-MS/MS technology to monitor the SAH production from the NSD2 enzymatic reaction. The enzymatic reaction was performed in white...More data for this Ligand-Target Pair
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Date in BDB:
11/6/2022
Entry Details
US Patent