BDBM5718 2,6,9-Trisubstituted purine deriv. 26::2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethan-1-ol::2-{[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino}ethanol::6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-methylpurine::CHEMBL280074::Olomoucine::purine deriv. 5
SMILES Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12
InChI Key InChIKey=GTVPOLSIJWJJNY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 51 hits for monomerid = 5718
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Universidad San Pablo Ceu
Universidad San Pablo Ceu
Affinity DataIC50: 7.00E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-33P] ATP. 33...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Bristol-Myers Squibb Pharmaceutical Research Institute
Affinity DataIC50: 7.00E+3nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Bristol-Myers Squibb Pharmaceutical Research Institute
Affinity DataIC50: 1.00E+6nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Universidad San Pablo Ceu
Universidad San Pablo Ceu
Affinity DataIC50: 7.00E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Universidad San Pablo Ceu
Universidad San Pablo Ceu
Affinity DataIC50: 7.00E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Universidad San Pablo Ceu
Universidad San Pablo Ceu
Affinity DataIC50: 7.00E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Universidad San Pablo Ceu
Universidad San Pablo Ceu
Affinity DataIC50: 4.60E+3nMpH: 7.4 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Bristol-Myers Squibb Pharmaceutical Research Institute
Affinity DataIC50: 1.20E+3nMpH: 7.4 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 0.17 mM ATP/[gamma-32P] ATP. 32P incorp...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 0.17 mM ATP/[gamma-32P] ATP. 32P incorp...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.More data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research
Curated by ChEMBL
National Organization For Drug Control & Research
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human recombinant CDK2/cyclin A expressed in baculovirus-infected insect Sf21 cells after 10 minsMore data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research
Curated by ChEMBL
National Organization For Drug Control & Research
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Cyclin A-cyclin-dependent kinase 2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of Jordan
Curated by ChEMBL
University Of Jordan
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human GST-CDK1/cyclin B1 expressed in baculovirus using [gamma-33P]ATP after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Cyclin B-cyclin-dependent kinase 1More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: >2.00E+6nMAssay Description:Inhibition of cAMP-dependent protein kinaseMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Bristol-Myers Squibb Pharmaceutical Research Institute
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Cyclin D1-cyclin-dependent kinase 4More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Cyclin E-cyclin-dependent kinase 2More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Mitogen-activated protein kinase 3 (MAPK-ERK1)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Mitogen-activated protein kinase 1 (MAPK-ERK2)More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 1 (CDK1)More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 5-p35nck5aMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Bristol-Myers Squibb Pharmaceutical Research Institute
Affinity DataIC50: 7.08E+3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research
Curated by ChEMBL
National Organization For Drug Control & Research
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CDK2/cyclin A expressed in baculovirus infected insect Sf21 cells using [gamma-P32]ATP and histone H1 as substrate after 10 mins by rad...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of Cyclin-dependent kinase 4 (CDK4/cyclin Dl)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 2 (CDK2/cyclin A)More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Compound was tested for its inhibitory activity against cyclin-dependent kinase 5More data for this Ligand-Target Pair
TargetMO15-related protein kinase Pfmrk(Plasmodium falciparum)
Institute Of Research
Curated by ChEMBL
Institute Of Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory activity against Plasmodium falciparum cyclin dependent protein kinase, PfmrkMore data for this Ligand-Target Pair
TargetMO15-related protein kinase Pfmrk(Plasmodium falciparum)
Institute Of Research
Curated by ChEMBL
Institute Of Research
Curated by ChEMBL
Affinity DataIC50: 1.10E+6nMAssay Description:Inhibition of Plasmodium falciparum cyclin-dependent kinaseMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibitory concentration against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 1.63E+5nMAssay Description:In vitro antiproliferative activity against myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Cdk6/cyclin D3Checked by AuthorMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CDK2/Cyclin EMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of ERK1/MAPKMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CDK2/Cyclin BMore data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
National Organization For Drug Control & Research
Curated by ChEMBL
National Organization For Drug Control & Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CDK2/cyclin AMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CDK2/cyclin EMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of Jordan
Curated by ChEMBL
University Of Jordan
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human CDK1/cyclinBMore data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at N-type Cav2.2 channel expressed in tsA201 cell assessed as calcium current by whole-cell patch clamp methodMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of Jordan
Curated by ChEMBL
University Of Jordan
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CDK1/cyclin B by MESACUP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute Of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of Jordan
Curated by ChEMBL
University Of Jordan
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CDK1/CyclinB (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Bristol-Myers Squibb Pharmaceutical Research Institute
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CDK2/cyclin EMore data for this Ligand-Target Pair