BDBM571957 2-{[(alphaR)-6-{2,5- dioxo-4-[2-(2,2,2- trifluoroethoxy)- ethyl]imidazolidin- 3-yl}spiro[3.3]- heptan-2-yl]oxy}- pyridine-3-carbox- amide::US11447487, Example 50::US11447487, Example 61

SMILES NC(=O)c1cccnc1O[C@H]1C[C@]2(C1)C[C@@H](C2)N1C(=O)NC(CCOCC(F)(F)F)C1=O

InChI Key InChIKey=IBJNABUAZLOBMO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 571957   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571957(2-{[(alphaR)-6-{2,5- dioxo-4-[2-(2,2,2- trifluoroe...)
Affinity DataIC50: 62nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM571957(2-{[(alphaR)-6-{2,5- dioxo-4-[2-(2,2,2- trifluoroe...)
Affinity DataIC50: 378nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent