BDBM572098 N-(4-((3S,4S)-3-fluoro-4- (quinazolin-2-ylamino)pyrrolidine-1- carbonyl)phenyl)acrylamide::US11447493, Example 63

SMILES F[C@H]1CN(C[C@@H]1Nc1ncc2ccccc2n1)C(=O)c1ccc(NC(=O)C=C)cc1

InChI Key InChIKey=GQFCNTKPAFRBKK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 572098   

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 572098BDBM572098(N-(4-((3S,4S)-3-fluoro-4- (quinazolin-2-ylamino)py...)
Affinity DataIC50: 550nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 572098BDBM572098(N-(4-((3S,4S)-3-fluoro-4- (quinazolin-2-ylamino)py...)
Affinity DataIC50: 5.50E+3nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Kinnate Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 572098BDBM572098(N-(4-((3S,4S)-3-fluoro-4- (quinazolin-2-ylamino)py...)
Affinity DataIC50: 2.00E+4nMAssay Description:A radiometric protein kinase assay (33PanQinase Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent