BDBM573611 US11453683, Example 196::US20230279025, Example 196

SMILES Fc1c(ncc2c(nc(OCC34CCCN3CCC4)nc12)N1CC2CCC(C1)N2)-c1cccc2OC(F)(F)Oc12

InChI Key InChIKey=UAMVNLCAIDIONQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 573611   

TargetGTPase KRas [G12D](Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM573611(US11453683, Example 196 | US20230279025, Example 1...)
Affinity DataIC50: 467nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetGTPase KRas [G12D](Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM573611(US11453683, Example 196 | US20230279025, Example 1...)
Affinity DataIC50: 467nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
Go to US Patent