BDBM575481 N,N′-(2,2′-dimethyl-[1,1′-biphenyl]-3,3′-diyl)bis(5-(((2-hydr oxyethyl)amino)methyl)picolinamide)::US11459339, Example 1::US12083118, Example 34

SMILES Cc1c(NC(=O)c2ccc(CNCCO)cn2)cccc1-c1cccc(NC(=O)c2ccc(CNCCO)cn2)c1C

InChI Key InChIKey=FZEPAZRIEAMJFE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 575481   

TargetProgrammed cell death 1 ligand/protein 1(Human)
Abbisko Therapeutics

US Patent
LigandPNGBDBM575481(US11459339, Example 1 | N,N′-(2,2′-dim...)
Affinity DataIC50: 0.170nMAssay Description:The effect of compounds and positive compounds of the examples of the present invention on the interaction between PD-1 and PD-L1 was determined by t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
US Patent

LigandPNGBDBM575481(US11459339, Example 1 | N,N′-(2,2′-dim...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human PD-1/PD-L1 interaction incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM575481(US11459339, Example 1 | N,N′-(2,2′-dim...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human PD-L1/PD-L1 interaction incubated for 15 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM575481(US11459339, Example 1 | N,N′-(2,2′-dim...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PD-1 (unknown origin)/PD-L1 (unknown origin) interaction by HTRF binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM575481(US11459339, Example 1 | N,N′-(2,2′-dim...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Fc-fused recombinant human PD-I/His-tagged recombinant human PD-L1 interaction incubated overnight by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Arbutus Biopharma

US Patent
LigandPNGBDBM575481(US11459339, Example 1 | N,N′-(2,2′-dim...)
Affinity DataIC50: 1nMAssay Description:PD-L1 His protein was prepared and added at the final concentration of 6 nM in the White opaque 384 well plate (Corning cat #3824BC). PD-L1 small mol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2025
Entry Details
US Patent

LigandPNGBDBM575481(US11459339, Example 1 | N,N′-(2,2′-dim...)
Affinity DataEC50:  15nMAssay Description:Inhibition of interaction of human PD-1 expressed in Jurkat T cells co-transfected with NFAT response element/human PD-L1 expressed in CHO-K1 cells c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM575481(US11459339, Example 1 | N,N′-(2,2′-dim...)
Affinity DataEC50:  17nMAssay Description:Inhibition of interaction of PD-1 (unknown origin) expressed in Jurkat T cells co-transfected with NFAT response element/PD-L1 (unknown origin) expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM575481(US11459339, Example 1 | N,N′-(2,2′-dim...)
Affinity DataEC50:  17nMAssay Description:Inhibition of PD-1/PD-L1 interaction in human Jurkat T cells co-cultured with CHO/TCRAct/PDL1 cells assessed as restoration of T cell activation meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed