BDBM575873 US11466016, Example 3::endo-8-[7-(4- chloro-2- methyl-2H- indazol-5-yl)- 5H-pyrrolo[2,3- b]pyrazin-3-yl]-8- azabicyclo[3.2.1] octan-3-amine

SMILES Cn1cc2c(Cl)c(ccc2n1)-c1c[nH]c2nc(cnc12)N1[C@H]2CC[C@@H]1C[C@H](N)C2

InChI Key InChIKey=XRNTZAQBJAFMBB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 575873   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575873(US11466016, Example 3 | endo-8-[7-(4- chloro-2- me...)
Affinity DataIC50: 10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575873(US11466016, Example 3 | endo-8-[7-(4- chloro-2- me...)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant C-terminal truncated human SHP2 (1 to 530 residues) using 6,8-difluoro-4-methylumbelliferyl phosphate as substrate and H2N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575873(US11466016, Example 3 | endo-8-[7-(4- chloro-2- me...)
Affinity DataIC50: 110nMAssay Description:Inhibition of SHP2 in human HCC827 cells harboring EGFR del 746 to 750 mutant assessed as inhibition of ERK phosphorylation incubated for 30 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed