BDBM575933 2-(5-{3-[endo-3-amino- 8-azabicyclo[3.2.1]oc- tan-8-yl]-5H- pyrrolo[2,3-b]pyrazin- 7-yl}-4-chloro- 2-methyl-2H-indazol-3- yl)acetonitrile::US11466016, Example 61

SMILES Cn1nc2ccc(-c3c[nH]c4nc(cnc34)N3[C@H]4CC[C@@H]3C[C@H](N)C4)c(Cl)c2c1CC#N

InChI Key InChIKey=PICHQFLKKRUMPP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575933   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575933(US11466016, Example 61 | 2-(5-{3-[endo-3-amino- 8-...)
Affinity DataIC50: 130nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent