BDBM575967 US11466016, Example 100::{6-[(1R,2S,3S,5S)- 3-amino-2-fluoro-8- azabicyclo[3.2.1]oc- tan-8-yl]-3-(5- chloro-3-methoxy- 2-methylquinolin- 6-yl)-1H-pyrazolo [3,4-b]pyrazin- 5-yl}methanol

SMILES COc1cc2c(Cl)c(ccc2nc1C)-c1n[nH]c2nc(N3[C@H]4CC[C@@H]3[C@@H](F)[C@@H](N)C4)c(CO)nc12

InChI Key InChIKey=HVQQCHQVTLUQNY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575967   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575967(US11466016, Example 100 | {6-[(1R,2S,3S,5S)- 3-ami...)
Affinity DataIC50: 12nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent