BDBM575973 (1R,2S,3S,5S)-8-[7- (5-chloro-3- methoxyquinoxalin- 6-yl)-5H- pyrrolo[2,3- b]pyrazin-3-yl]-2- fluoro-8- azabicyclo[3.2.1]oc- tan-3-amine, hydrochloride::US11466016, Example 106

SMILES COc1cnc2ccc(-c3n[nH]c4nc(cnc34)N3[C@H]4CC[C@@H]3[C@@H](F)[C@@H](N)C4)c(Cl)c2n1

InChI Key InChIKey=LSHINCKAZDLLON-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575973   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575973(US11466016, Example 106 | (1R,2S,3S,5S)-8-[7- (5-c...)
Affinity DataIC50: 22nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
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