BDBM575983 US11466016, Example 118::{6-[(1R,2S,3S,5S)- 3-amino-2-fluoro-8- azabicyclo[3.2.1]oc- tan-8-yl]-3-[5- chloro-3- (dimethylamino)qui- noxalin-6-yl]-1H- pyrazolo[3,4- b]pyrazin-5- yl}methanol

SMILES CN(C)c1cnc2ccc(-c3n[nH]c4nc(N5[C@H]6CC[C@@H]5[C@@H](F)[C@@H](N)C6)c(CO)nc34)c(Cl)c2n1

InChI Key InChIKey=JABIEEOYCYLUIX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 575983   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575983(US11466016, Example 118 | {6-[(1R,2S,3S,5S)- 3-ami...)
Affinity DataIC50: 5.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent