BDBM578953 4-((5-(4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin- 6-yl)pyridin-3-yl)oxy)benzonitrile::US11479551, Example 7-6::US11492351, Example 7-6

SMILES N#Cc1ccc(Oc2cncc(-c3ccc4c(=O)[nH]nc(CN)c4c3)c2)cc1

InChI Key InChIKey=BNMGLZSQZXLQOL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 578953   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 578953BDBM578953(US11492351, Example 7-6 | 4-((5-(4-(aminomethyl)-1...)
Affinity DataIC50: 18nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 578953BDBM578953(US11492351, Example 7-6 | 4-((5-(4-(aminomethyl)-1...)
Affinity DataIC50: 18nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 578953BDBM578953(US11492351, Example 7-6 | 4-((5-(4-(aminomethyl)-1...)
Affinity DataIC50: 577nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 578953BDBM578953(US11492351, Example 7-6 | 4-((5-(4-(aminomethyl)-1...)
Affinity DataIC50: 577nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent