BDBM579038 4-(aminomethyl)-6-(5-(2-fluorophenyl)-1- methyl-1H-pyrazol-4-yl)phthalazin-1(2H)- one::US11479551, Example 4-142::US11492351, Example 4-142

SMILES Cn1ncc(c1-c1ccccc1F)-c1ccc2c(c1)c(CN)n[nH]c2=O

InChI Key InChIKey=NOQIGSIFVHEIBI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 579038   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM579038(US11492351, Example 4-142 | US11479551, Example 4-...)
Affinity DataIC50: 881nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM579038(US11492351, Example 4-142 | US11479551, Example 4-...)
Affinity DataIC50: 881nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent