BDBM579048 2-(4-(4-(aminomethyl)-8-chloro-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5- yl)-1-naphthonitrile::US11479551, Example 10-1::US11492351, Example 10-1

SMILES Cn1ncc(-c2cc(Cl)c3c(=O)[nH]nc(CN)c3c2)c1-c1ccc2ccccc2c1C#N

InChI Key InChIKey=FCYGAQJCBSYGFT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 579048   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 579048BDBM579048(US11492351, Example 10-1 | 2-(4-(4-(aminomethyl)-8...)
Affinity DataIC50: 41.7nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 579048BDBM579048(US11492351, Example 10-1 | 2-(4-(4-(aminomethyl)-8...)
Affinity DataIC50: 41.7nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent