BDBM579065 2-(4-(4-(aminomethyl)-8-fluoro-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5- yl)-6-ethoxybenzonitrile::US11479551, Example 10-10::US11492351, Example 10-10

SMILES CCOc1cccc(-c2c(-c3cc(F)c4c(=O)[nH]nc(CN)c4c3)cnn2C)c1C#N

InChI Key InChIKey=WBUIDMYGYDRZRP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 579065   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 579065BDBM579065(US11492351, Example 10-10 | 2-(4-(4-(aminomethyl)-...)
Affinity DataIC50: 2.73E+3nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 579065BDBM579065(US11492351, Example 10-10 | 2-(4-(4-(aminomethyl)-...)
Affinity DataIC50: 2.73E+3nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent