BDBM579068 2-(4-(4-(aminomethyl)-8-methyl-1-oxo-1,2- dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5- yl)-6-cyclopropoxybenzonitrile::US11479551, Example 10-12::US11492351, Example 10-12

SMILES Cc1cc(-c2cnn(C)c2-c2cccc(OC3CC3)c2C#N)cc2c(CN)n[nH]c(=O)c12

InChI Key InChIKey=RKAROHNLJYSDRI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 579068   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 579068BDBM579068(US11492351, Example 10-12 | 2-(4-(4-(aminomethyl)-...)
Affinity DataIC50: 155nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Mirati Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 579068BDBM579068(US11492351, Example 10-12 | 2-(4-(4-(aminomethyl)-...)
Affinity DataIC50: 155nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent